Hope for Lupus

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Ciri-ciri terkena LUPUS

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Ciri-ciri terkena LUPUS

Lupus on Skin

 

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Discoid Lupus

 

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LUPUS on Hair

 

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LUPUS on the Joints

 

The majority of lupus patients suffer from aches and pains. During a severe attack, these may occur all over the body, affecting muscles, ligaments and joints. In the teenager, the joint pains may be passed off as "growing pains" - it is common, for example, to see pain limited to both knees. (Some years ago, SLE patients were often wrongly diagnosed as having rheumatic fever - a disease now almost extinct in major western countries). In older patients, the patient may be suspected of suffering from rheumatoid arthritis. The joint disease of SLE differs, however, from rheumatoid arthritis. To put it in more emotive terms, for the vast majority of patients worldwide, SLE arthritis is not a crippling disease.

 

Lupus Symptoms on Tendons

 

Perhaps the most common rheumatic feature of active lupus is inflammation in tendons. The patient may not, for example, be able to stretch the fingers flat - "saying ones prayers". Occasionally, this abnormal pull by tendons on the joints may lead to deformity. An unusual, though almost characteristic change is the "lupus thumb" - a locking back into the "hitchhiking" position. This tendency of the inflammation of tendons waxes and wanes as do so many of the features of lupus. It is often the only sign of disease activity in an otherwise symptom-free lupus patient.

 

Hand and xray of a hand showing a patient with Lupus and chronic tendon inflammation leading to deformities including the "hitch-hiking thumb".

 

The symptoms of Lupus on Veins and Arteries

 

  1. Inflammation of veins - "thrombophlebitis" is an occasional complication of lupus, though of course, it is a common enough medical problem on its own. Inflammation in small arteries is obviously capable of producing symptoms anywhere in the body.
  2. In the skin, there may be red or spotty rashes. In the kidney, it may produce a disturbance of kidney blood flow and in the brain, it may produce any number of features, from mild depressive attacks to more gross features such as a seizure.

 

Lupus Symptoms on Heart and Lungs

 

  1. It is the linings of the heart and lungs - the so-called pericardium and pleura - which are most frequently affected. By far the commonest complaint is of pleurisy - sharp pains in the lower parts of the chest (usually round the side or at the back) on breathing deeply in.
  2. In more severe illness, fluid may develop in the space between the layers of the pleura or pericardium and lead to shortness of breath. Serious though these problems are, they usually respond readily to lupus treatment. Chronic heart or lung disease are, fortunately, more unusual in lupus.

 

Lupus Symptoms on the Brain

 

  1. There is still uncertainty as to how frequently the brain is affected in SLE ( Systemic Lupus Erythematosus) . This uncertainty is partly because diagnosis of mild brain involvement is very difficult. It is very difficult to be sure clinically, for example whether an attack of depression in lupus is simply the natural reaction to a bad disease and its treatment, or whether it represents the (albeit mild) effects of inflammation in brain tissues. The brain (as is the case with other organs) has only a limited number of ways of reacting to "insults" such as inflammation - there can be disturbances of the normal thought processes (eg depression, hallucinations, odd behaviour), or there can be more marked abnormalities such as an attack of epilepsy, or the development of severe migraines.
  2. It is evident that mild episodes of brain involvement during active lupus are extremely common. If true, this has important implications for families, nurses and medical attendants of lupus patients - to understand that an attack of mental depression, for example, may be due to the disease.
  3. One of the more positive aspects about managing SLE is that these neurological features get better - they generally leave no damage.
  4. One of the intriguing factors of the link with brain disease in lupus is that a number of patients with lupus, first developing at say, twenty, give a past history of epilepsy as a child. It is tempting to think that these symptoms are related - possibly that the lupus had been present all along. The question of fitness to drive is a difficult one in the adult SLE patient who has had a seizure during an acute flare. While such a patient may well never have another attack in her life, at the present time there are no medical tests sufficiently clear-cut to convince the powers of the law that lupus patients can be treated more compassionately. (At the present time, patients who have had a seizure are banned from driving for two years in the UK).

 

Lupus symptoms on the Kidney

 

  1. The kidney is one of the body's most delicate organs. It differs from the other organs involved in lupus in that it has limited powers of healing. Having said this, we now know that even those patients with active kidney disease can and do, improve enough to come off all medication.
  2. Lupus nephritis, as it is called, is produced by two main factors - deposition of the proteins discussed earlier in the delicate filtering apparatus of the kidney, and inflammation of the blood vessels supplying the kidney.
  3. The kidney protests in three main ways - it becomes "leaky", and protein is detected in the urine, the blood pressure may rise (only in more severe cases), and chemical impurities normally excreted in the urine accumulate in the blood.
  4. Of all the features of lupus, kidney involvement is the most subtle. While joint pains or a rash may quickly bring the patient to the doctor, a "smouldering" inflammation in the kidney may go undetected until irreversible damage is done.
  5. It is for this reason that lupus nephritis has the bad reputation it does. Conversely, it is obvious that in a patient who is diagnosed as having lupus and in whom there is no major kidney involvement, severe kidney inflammation can usually be thwarted.
  6. In the patient whose disease has "gone into remission" (i.e gone away) - it is wise to check the urine every few months.
  7. Because of the limited ways in which kidney disease may show itself, it may be necessary to perform a needle biopsy - largely to see just how much protein deposition and inflammation there is. Obviously this will influence the choice of how much treatment is needed.
  8. Traditionally, textbooks have tended to quote a figure of 40-50% for "significant" kidney involvement in lupus.
  9. It is almost certain that as milder (and earlier) cases of lupus are diagnosed, this figure will fall. In Graham R V Hughes' practice (and this still probably concentrates on patients with more severe disease) the figure is now nearer 20%.

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